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Dr Amitabh Jha,
M.Sc., Ph.D. (Delhi)
Research Articles: (underline
indicates research trainees)
74. |
Jha A*, Mohapatra PP,
AlHarbi SA,
Jahan N. Curcumin: Not so spicy afterall.
Mini-Reviews in Medicinal Chemistry, accepted (2016). |
|
73. |
O'Brien M,
Weagle, R,
Corkum D, Kuanar M,
Mohapatra PP, Jha A*. Convenient
access to 5-arylisoindolo[2,1-a]quinolin-11(6aH)-ones.
Molecular Diversity, in press (2016). |
|
72. |
Mukherjee C,
Mohapatra PP,
Youssef D, Jha A*. Optical
enrichment in enzyme-catalyzed resolution of
1-aryl-2,2-dimethyl-1,3-propanediols. Canadian Journal
of Chemistry, in press, (2016). |
|
71. |
Al-Jaroudi Z,
Mohapatra PP, Cameron TS, Jha
A*. Expedient and diastereoselective synthesis of
substituted 6,6a-dihydroisoindolo[2,1-a]quinolin-11(5H)-ones.
Synthesis, 48, 4477-4488 (2016). |
|
70. |
Al-Jaroudi Z,
Mohapatra PP, Jha A*. Facile synthesis of 3-substituted isoindolinones. Tetrahedron Letters, 57,
772-777 (2016). |
|
69. |
Bhullar KS,
Jha A, Rupasinghe HPV*. Novel carbocyclic curcumin analog CUR3d modulates genes
involved in multiple apoptosis pathways in human
hepatocellular carcinoma cells.
Chemico-Biological Interactions, 242, 107-122 (2015). |
|
68. |
Jha A,* Duffield KM,
Ness MR,
Ravoori S, Andrews G,
Bhullar KS, Rupasinghe HPV,
Balzarini J. Curcumin-inspired cytotoxic
3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors.
Bioorganic and Medicinal Chemistry,
23, 6404-6417 (2015). |
|
67. |
Abdelkhalik AM,
Paul NK, Jha A*. Concise synthesis of 12a-methyl-11-aryl-1,2-dihydrobenzo[f]pyrrolo[1,2-a]quinolin-3(12aH)-ones
as racemic 14-azaestrogen analogs. Steroids,
98, 117-113 (2015). |
|
66. |
Potter E,
Jha M,
Bhullar K, Rupasinghe HPV, Balzarini J, Jha A*. Investigation of fatty acid conjugates of
3,5-bisarylmethylene-4-piperidone derivatives as antitumor
agents and human topoisomerase-IIα
inhibitors. Bioorganic and Medicinal Chemistry, 23,
411-421 (2015). |
|
65. |
Jha A*,
Yadav Y,
Naidu AB, Rao VK, Kumar
A, Parmar VS, MacDonald WJ, Too
CKL, Balzarini J, Barden CJ, Cameron TS.
Design, synthesis and bioevaluation of novel
6-(4-hydroxypiperidino)naphthalen-2-ol-based potential
selective estrogen receptor modulators for breast cancer.
European Journal of Medicinal Chemistry,
92, 103-114
(2015). |
|
64. |
Paul NK,
Jha M,
Bhullar K, Rupasinghe HPV, Balzarini J, Jha A*.
All trans
1-(3-arylacryloyl)-3,5-bis(pyridin-4-ylmethylene)piperidin-4-ones
as curcumin-inspired antineoplastics. European Journal of Medicinal Chemistry,
87, 461-470 (2014). |
|
63. |
Mathur D,
Prasad AK, Cameron TS, Jha A*.
Novel approach to
3,3-dimethyl-4-morpholino-3,4-dihydro-coumarins via hetero-Diels-Alder reaction. Tetrahedron,
70, 5608-5618(2014). |
|
62. |
Jha A*,
Chou T-Y,
ALJaroudi Z, Ellis BD, Cameron
TS.
Aza-Diels-Alder
Reaction between N-aryl-1-oxo-1H-isoindolium ions and tert-enamides:
Steric effects on reaction outcome.
Beilstein Journal of
Organic Chemistry, 10,
848-857
(2014). |
|
61. |
Jha A*,
Naidu AB,
Abdelkhalik AM.
Transition metal-free one-pot cascade synthesis of
7-oxa-2-azatricyclo[7.4.0.02,6]trideca-1(9),10,12-trien-3-ones
from biomass-derived levulinic acid under mild conditions.
Organic & Biomolecular Chemistry, 11,
7559-7565
(2013). |
|
60. |
Pericherla K,
Jha A,
Khungar B,
Kumar A*. Copper-catalyzed tandem azide-alkyne
cycloaddition, Ullmann type C-N coupling, and intramolecular
direct arylation.
Organic Letters, 15,
4304-4307
(2013). |
|
59. |
Pericherla K,
Kumar A,
Jha A*.
Povarov-reductive amination cascade to access
6-aminoquinolines and anthrazolines.
Organic Letters, 15,
4078-4081
(2013). |
|
58. |
Bhullar KS,
Jha A,
Youssef D,
Rupasinghe HPV*.
Curcumin ands its carbocyclic
analogs: Structure-activity in relation to antioxidant
and selected biological properties. Molecules,
18,
5389-5404
(2013). |
|
57. |
Jha A*,
Chou T-Y,
Vaughan D.
An efficient and expeditious synthesis of novel
2,2-dialkyl-2,3-dihydrobenzofurans from phenols and
2,2-dialkylacetaldehydes. Molecular Diversity,
17, 261-270
(2013). |
|
56. |
Vaughan D,
Naidu AB, Jha A*.
One-pot annulation of 2-naphthol analogs to heterocycles.
Current Organic Synthesis,
9, 613-649
(2012). |
|
55. |
Yadav Y,
MacLean ED,
Bhattacharyya A, Parmar VS, Balzarini J, Barden C,
Too CKL, Jha A*.
Design, synthesis, and bioevalaution of novel candidate
selective estrogen receptor modulators. European
Journal of Medicinal Chemistry,
46, 3858-3866
(2011). |
|
54. |
Jha A*, Mukherjee C,
Prasad AK, Parmar VS, Vadaparti M,
Das U, De Clercq E, Balzarini J, Stables JP, Shrivastav A,
Sharma RK, Dimmock JR.
Derivatives of aryl amines containing the cytotoxic
1,4-dioxo-2-butenyl pharmacophore.
Bioorganic and Medicinal Chemistry
Letters,
20, 1510-1515
(2010). |
|
53. |
Huang P-JJ,
Potter E,
Jha A*.
Novel and convenient synthesis of 1-(pyridinylmethyl)-2-naphthols
and 1-(pyridinylmethylene)-2-tetralones from 2-tetralones. Molecular Diversity,
14,
393-400
(2010). |
|
52. |
Mukherjee C,
MacLean ED, Cameron TS, Jha A*.
Enzyme-assisted kinetic resolution of novel 2-naphthol
Mannich bases.
Journal of Molecular
Catalysis B: Enzymatic,
62,
46-53
(2010). |
|
51. |
Huang P-JJ,
Jha A*.
Synthetic approaches to 3H-naphtho[2,1-b]pyrans
and 2,3-dihydro-1H-naphtho[2,1-b]pyrans. Journal of Heterocyclic Chemistry,
46,
1098-1106
(2009). |
|
50. |
Youssef D, Potter E,
Jha M, DeClercq E, Balzarini J, Stables JP, Jha A*.
Design, synthesis and
bioevaluation of novel maleamic amino acid ester conjugates
of 3,5-bisarylmethylene-4-piperidones as cytostatic agents.
Bioorganic and Medicinal Chemistry
Letters,
19, 6364-6367
(2009). |
|
49. |
Vaughan D,
Jha A*.
Convenient synthesis of
novel 2,2-dialkyl-1,2-dihydronaphtho[2,1-b]furans. Tetrahedron Letters,
50, 5709-5712
(2009). |
|
48. |
Huang P-JJ,
Cameron TS,
Jha A*.
Novel
synthesis of 2,2-dialkyl-3-dialkylamino-2,3-dihydro-1H-naphtho[2,1-b]pyrans. Tetrahedron Letters,
50, 51-54
(2009). |
|
47. |
McDonald
GR, Hudson AL, Dunn SMJ, You H, Baker GB, Whittal RM, Martin
JW, Jha A, Edmondson DE, Holt A*. Bioactive
contaminants leach from disposable laboratory plasticware.
, 322, 917 (2008). |
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46. |
Huang P-JJ,
Youssef D,
Cameron TS,
Jha A*.
Microwave-assisted synthesis of novel 2-naphthol
bis-Mannich bases.
Arkivoc,
xvi, 165-177
(2008). |
|
45. |
Jha A*,
Huang P-JJ, Mukherjee C, Paul NK.
A convenient one-pot synthesis of 2,2-dialkyl-2,3-dihydro-1H-naphtho[2,1-b]pyrans. SynLett
3127-3130
(2007). |
|
44. |
Youssef D,
Nichols CE, Cameron TS,
DeClercq E, Balzarini J,
Jha A*. Design, synthesis and cytostatic activity of
novel cyclic curcumin analogs.
Bioorganic and Medicinal Chemistry Letters,
17,
5624-5629
(2007). |
|
43. |
Jha A*, Mukherjee C,
Rolle AJ, DeClercq E, Balzarini J, Stables JP.
Cytostatic activity of novel 4'-aminochalcone-based
imides.
Bioorganic and Medicinal Chemistry
Letters,
17,
4545-4550
(2007). |
|
42. |
Jha A*, Mukherjee C,
Prasad AK, Parmar VS, DeClercq E, Balzarini J, Stables JP,
Manavathu EK, Shrivastav A, Sharma RK, Nienaber KH, Zello
GA, Dimmock JR.
E,E,E-1-(4-Arylamino-4-oxo-2-butenoyl)-3,5-bis(arylidene)- 4-piperidones:
a topographical study of some novel potent cytotoxins.
Bioorganic and Medicinal Chemistry,
15,
5854-5865 (2007). |
|
41. |
Paul
NK,
Dietrich L,
Jha A*. Convenient synthesis of
1-arylmethyl-2-naphthols. Synthetic Communications,
37, 877-888 (2007). Highlighted in
ChemInform, 38, 103 (2007). |
|
40. |
Duffield KM,
Jha A*. 3,5-Bis(arylmethylene)-4-piperidone
derivatives as novel anticancer agents.
Indian Journal of Chemistry, 45B, 2313-2320 (2006). |
|
39. |
Nichols CE, Youssef D, Harris RG,
Jha A*.
Microwave-assisted synthesis of curcumin
analogs. Arkivoc,
XIII,
64-72 (2006). |
|
38. |
Jha A*,
Zhao J, Cameron TS, DeClercq E, Balzarini J, Manavathu EK,
Stables JP. Design, synthesis and biological evaluation of
novel curcumin analogs as anti-neoplastic agents.
Letters
in Drug Design & Discovery,
3, 304-310 (2006). |
|
37. |
Jha A*,
Paul NK, Trikha S, Cameron TS.
Novel synthesis of 2-naphthol Mannich bases and their
dynamic NMR behaviour.
Canadian Journal of Chemistry, 84,
843-853 (2006). |
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36. |
Prasad AK*, Mukherjee C, Sharma D, Rastogi S,
Jha A,
Olsen CE, Parmar VS.
Synthesis and lipase-catalyzed resolution studies on novel
(±)-2-(2-acetoxyethyl)-4-arylmethyl-3-oxo-3,4-dihydo-2H-1,4-benzoxazine-6-carboxylates.
Journal
of Molecular Catalysis B: Enzymatic,
40, 101-110 (2006). |
|
35. |
Jha A,
Dimmock JR*. 1-N-(Arylmaleamoyl)-3,5-bis(phenylmethylene)-4- piperidones:
a novel class of antimycobacterial agents. Pharmazie,
61, 562-563 (2006). |
|
34. |
Jha A*. Unusual synthesis
of 1-(4-fluorobenzyl)-N-(1-(1-(4-fluorobenzyl)-6- isopropoxy-1H-benzo[d]imidazol-2-ylpiperidin-4yl(-6-isopropoxy-1H-benzo[d] imidazol-2-amine.
Arkivoc,
I,
13-20 (2006). |
|
33. |
Ma G,
Jha A*.
A practical guide for buffer-assisted isolation and
purification of primary, secondary and tertiary amine
derivatives from their mixture. Organic Process Research
and Development, 9, 847-852 (2005). |
|
32. |
Jha A*,
Beal J.
Convenient synthesis of 12H-benzo[a]xanthenes from
2-tetralone.
Tetrahedron Letters,
45, 8999-9001 (2004). |
|
31. |
Jha A*,
Dimmock JR. Convenient, tandem and one-reaction vessel synthesis of
mixed 1-alkyl-2-alkoxynaphthalenes from 2-tetralone. Canadian
Journal of Chemistry, 81, 293-296 (2003).
|
|
30. |
Jha A*, Padmanilayam MP, Dimmock JR.
Conversion of substituted 1-arylidene-2-tetralones to
1-arylmethyl-2-alkoxynaphthalenes: An example of facile
aromatization.
Synthesis, 463-465 (2002). |
|
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Publications of Dr Jha as a Doctoral or Postdoctoral Trainee |
|
29. |
Stepkowski
SM, Kao J, Wang M-E, Tejpal N, Podder H, Furian L, Dimmock
J,
Jha A, Das U, Kahan BD, Kirken RA*. The Mannich base
NC1153 promotes long-term allograft survival and spares the
recipient from multiple toxicities. Journal of Immunology,
175, 4236-4246, (2005). |
|
28. |
Jha A, Dimmock JR*.
Synthesis of
4-(3,5-dibenzylidene-4-oxo-piperidin-1-yl)- 4-oxo-but-2-enoic
acid arylamides as potential cytotoxic agents. Synthetic Communications,
33,
1211-1223 (2003). |
|
27. |
Dimmock JR*,
Jha A, Zello GA, Sharma RK, Shrivastav A, Allen TM,
Santos CL, Balzarini J, DeClercq E, Manavathu EK, Stables
JP. 3,5-Bis (phenylmethylene)-1-(N-arylmaleamoyl)-4-piperidones:
a novel group of cytotoxic agents. Journal of Enzyme
Inhibition and Medicinal Chemistry, 18, 325-332,
(2003). |
|
26. |
Parmar VS*, Sharma
NK, Husain M, Watterson AC, Kumar J, Samuelson LA, Cholli AL, Prasad
AK, Kumar A, Malhotra S, Kumar N, Jha A, Singh A, Singh I,
Himanshu, Vats A, Shakil NA, Trikha S, Mukherjee S, Sharma SK, Singh
SK, Kumar A, Jha HN, Olsen CE, Stove CP, Bracke ME, Mareel MM.
Synthesis, characterization and in vitro anti-invasive activity
screening of polyphenolic and heterocyclic compounds.
Bioorganic and Medicinal Chemistry,
11, 913-929 (2003). |
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25. |
Dimmock JR*, Jha A, Zello, GA, Allen TM, Santos CL,
Balzarini J, DeClercq E, Manavathu EK, Stables JP. Cytotoxic
4’-aminochalcones and related compounds. Pharmazie,
58, 227-232 (2003). |
|
24. |
Dimmock JR*, Jha A, Zello GA, Quail JW, Oloo EO,
Nienaber KH, Kowalczyk ES, Allen TM, Santos CL, DeClercq E,
Balzarini J, Manavathu EK, Stables JP. Cytotoxic N-[4-(3-aryl-3-oxo-1-propenyl)phenylcarbonyl]-3,5-bis(phenylmethylene)-4-piperidones
and related compounds.
European Journal of Medicinal Chemistry,
37,
961-972 (2002). |
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23. |
Dimmock JR*, Jha A, Kumar P, Zello GA, Quail JW, Oloo
EO, Oucharek JJ, Pasha MK, Sharma RK, Allen TM, Santos CL,
Manavathu EK, DeClercq E, Balzarini J, Stables JP.
Cytotoxicity of 1,4-bis(2-oxo-1-cycloalkylmethylene)benzenes
and related compounds. European Journal of Medicinal
Chemistry, 37, 35-44 (2002). |
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22. |
Dimmock JR*, Kumar
P, Jha A, Quail JW. Synthesis and cytotoxicity of
1-phenyl-3,3-diacetoxy-1-propene.
Pharmazie,
56, 744-745 (2001). |
|
21. |
Parmar VS*, Singh SK, Prasad AK, Jha A, Kumar A,
Jennings KR. Mass fragmentation pattern of (Z)-2-(5-arylpyrazol-3-yl)-3-arylacrylonitriles.
Indian Journal of Chemistry,
39B, 915-920 (2000). |
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20. |
Jha A,
Malhotra S, Parmar VS, Errington W
.
6-Hydroxy-2,2-dimethyl-3,4- dihydro-2H-benzo{b}pyran.
Acta Crystallographica C56,
899-900 (2000). |
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19. |
Parmar VS*,
Sharma SK, Malhotra S, Jha A, Errington W, Howarth
OW, Puar M. Biocatalytic resolution of racemic
6-acetyl-3,4-dihydro-3-hydroxy-7- methoxy-2,2-dimethyl-2H-1-benzopyran.
Indian Journal of Chemistry 38B, 1231-1233 (1999). |
|
18. |
Gupta S, Jha A, Prasad AK, Rajwanshi VK, Jain SC,
Olsen CE, Wengel J, Parmar VS*. A new amide, N-cinnamoylpyrrole
and other constituents from Piper argyrophylum.
Indian Journal of Chemistry 38B, 823-827 (1999). |
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17. |
Parmar VS*, Jha A, Bisht KS, Taneja P, Singh, SK,
Kumar A, Poonam, Jain R, Olsen CE. Constituents
of the yew trees (Review).
Phytochemistry 50 1267-1304 (1999). |
|
16. |
Jha A,
Malhotra S, Parmar VS, Errington W*.
6-Acetyl-3,4-dihydro-2,2- dimethyl-2H-benzopyran-3,7-diyl
diacetate.
Acta Crystallographica
C54, 361-363 (1998). |
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15. |
Parmar VS*, Jain SC, Bisht KS, Sharma NK, Himanshu, Gupta S, Prasad AK, Jha A,
Poonam, Malhotra S, Sharma SK, Bracke ME, Errington W, Olsen CE,
Wengel J. Synthesis and anti-invasive activity of novel
1,3-diarylprop-2-enones. Indian Journal of Chemistry 37B,
628-643 (1998). |
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14. |
Parmar VS*, Jain SC, Jha A, Kumar N, Kumar A, Vats A, Jha HN, Mukherjee, S, Singh
SK, Jennings KR, Summerfield SG, Errington W, Olsen CE.
Synthetic and mass spectral fragmentation studies on
trisubstituted 2H-pyrans and comparative EIMS
behavior of biologically active 3,5-disubstituted pyrazoles
and isoxazoles. Indian Journal of Chemistry 36B,
872-879 (1997). |
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13. |
Parmar VS*, Jain SC, Bisht KS, Jain R, Taneja P,
Jha A,
Tyagi OD, Prasad AK, Wengel J, Olsen CE, Boll PM.
Phytochemistry of the genus Piper
(Review). Phytochemistry 46 597-673 (1997). |
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12. |
Raj HG, Gupta S,
Biswas G, Singh S, Singh A, Jha A, Bisht KS, Sharma SK, Jain
SC, Parmar VS*. Chemoprevention of carcinogen-DNA binding: The
relative role of different oxygenated substituents on
4-methylcoumarins in the inhibition of Aflatoxin B1-DNA
binding in-vitro. Bioorganic and Medicinal Chemistry
4,
2225-2228 (1996). |
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11. |
Singh SK, Prasad AK,
Olsen CE, Jha A, Jain SC, Parmar VS, Wengel J*. Neolignans and
alkaloids from Piper argyrophylum. Phytochemistry
43, 1355-1360 (1996). |
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10. |
Parmar VS*, Bisht KS,
Singh A, Jha A. Chiral discrimination by hydrolytic enzymes
in the synthesis of optically pure materials. (Review).
Proceeding of
Indian
Academy of Sciences: Chemical Sciences
108 575-583 (1996). |
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9. |
Tyagi OD, Prasad AK, Wengel J, Boll PM, Olsen CE, Parmar VS,
Sharma NK, Jha A, Bisht KS. Neolignans from Piper
schmidtii and reassignment of the structure of
schmiditin. Acta Chemica Scandinavica 49
142-148 (1995). |
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8. |
Parmar VS*, Bisht KS, Malhotra A, Jha A, Errington W,
Howarth OW, Tyagi OD, Stein PC, Jensen S, Boll PM, Olsen CE.
A benzoic acid ester from Uvaria narum.
Phytochemistry 38 951-955 (1995). |
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7. |
Parmar VS*, Jain R, Sharma SK, Vardhan A, Jha A,
Taneja P, Singh S, Vyncke BM, Bracke ME, Mareel MM.
Anti-invasive activity of 3,7-dimethoxyflavone in-vitro.
Journal of Pharmaceutical Sciences 83,
1217-1221 (1994). |
|
6. |
Jha A,
Bisht KS, Parmar VS*. Potentially useful lipase-catalyzed transesterifications (Review). Proceeding of
Indian Academy of
Sciences: Chemical Sciences
106 1191-1202 (1994). |
|
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Book Chapters, Technical Reviews and Non-refereed
Articles |
|
5. |
Youssef D,
Nichols CE,
Jha A*.
Efficient and environmentally benign
synthesis of bis-Mannich bases of 2-naphthol.
Polyphenol Communications,
267-268 (2006). |
|
4. |
Paul NK,
Dietrich L, Jha A*. Novel synthesis of
1-arylmethyl-2-naphthols via Mannich reaction followed by
reductive deamination. Proceedings of International
Congress of Chemistry and Environment, 673-677 (2005). |
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3. |
Jha A*. ChemOffice
Ultra 2002: ChemDraw, ChemFinder, BioAssay, E-Notebook (Invited
Review).
ChemNews.Com, 12, 18-19 (2002). |
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2. |
Parmar VS*,
Jha A.
Chemical constituent of Taxus species (Book Chapter).
Studies in Natural Products Chemistry Ed. Atta-ur-Rehman,
Elsevier Science BV, Amsterdam, The Netherlands 20
79-133 (1998). |
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1. |
Jha A,
Bisht KS, Parmar VS*. Scenario of research at doctoral and
post-doctoral levels in India vis-à-vis in developed countries (Invited
Review).
Research Training for Development Ed. EW Thulstrup, Roskilde
University Press (Denmark) 33-42 (1996). |
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